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Carcinogenesis In the life time carcinogenicity analyze carried out in B6C3F1 mice, methylphenidate brought about an increase in hepatocellular adenomas, and in males only, a rise in hepatoblastomas at a every day dose of about 60 mg/kg/working day. This dose is close to 2 occasions the MRHD of sixty mg/day given to children on mg/m2 basis.Though s